Mrs pink you're in a very similar situation to me, i was on depot for 5 yrs as i've had 2 spontaneous dvts aged 18 and 19 and so been on lifelong warfarin since, i gained 6 stone since being on the depot and i know it's not entriely attributed to the depot but it doesn't help, also found it extrememly difficult to lose weight whilst on the depot, have been off it for 6 months and on mini pill and still struggling to lose weight, the CD wont affect how the depot works if anything it'll work better as there'll be more progesterone to go in a smaller space...same kind of reason why some mini pills if you're over a certain weight you may have to take 2 tablets. Good luck with the CD, i'm on day 5 and my tummy is really grumlbing


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