I take a high dose of citalopram and beta blockers (both for chronic anxiety) which slow down your metabolism. I've struggled like mad losing weight on every plan I've tried, except lighter life, but to be honest that was a miserable diet. On Dukan, I'm having amazing results. I've been doing the plan 14 days and I've lost 8 lbs! - I finally believe that I've found a plan where I can drop the weight at a pace that can keep me motivated because I have a lot of weight to lose!!