DON'T!!!!!!! I used it last week and it completely bloated me up, kicked me out of ketosis and left me with terrible stomach cramps, not to mention what your stool is gonna be like when you go..... I spoke to LT headquarters about Regucol and they told me not to use it, but use senokot instead. Someone else here on the forum takes 2 tablets before she goes to bed and she has no problem with going. I'm gonna give that a try too as I don't like the cramps you get when you have to take dulcolax.