I've also had a good experience with Xenical/Orlistat. I've lost 4 stone 9 pounds since August 2011, and as I do no exercise at all due to health problems, and am still eating 1600 calories a day, I'm very pleased with that.
I'm still managing to get Orlistat ok from my local Co-op Pharmacy - they didn't have it for a month or so, but now they have it in (the Teva brand of Orlistat, not the Xenical, which is made by Roche, but it's exactly the same). x