I have just been put on orlistat by my doc however I have yet to take any of them. But having read all the postings on here Im about to embark on them tomorrow I am 16st and need to lose 6st there is no hurry I can do it in my own time but Im sick of being out of breath and not being able to fit into anything nice. will keep you updated and its so nice to find a forum that appears to care.