Can I substitute any sugar for sweetener in any cake recipe??

My cousin just bought me the "Cupcakes from the Primrose Bakery" recipe book :D and I would love to try all the recipes out! But I quickly calculated the amount of syns for the ingredients and it went up to a staggering 24 syns per cupcake (and even the lamest vanilla cupcake with vanilla frosting).

I've already switched the full-fat butter for reduced fat and the syns have gone down, but can I switch the sugar for sweetener (splenda) and keep the same taste?

:confused::confused::confused:
 
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