Hi charley! I have the depot and have been having issues for the past couple of months i seem to only have a day or so where i'm not on. it's really frustrating and would be interested to know if it is because of CD - can't really see it being anything else! i have had a look on the FAQs but there isn't any proper mention of it. Might switch to the pill for a couple of months and see if that stops the problem but the depot has always worked well for me as i really don't like TOTM.