I went to sainsburys earlier to buy some ducolax and I took two about 3.30, I have not had to use these before but am coming up to week 10 and haven't been for 5 days, this has caused me to have quite bad cramps after my packs so it was my only solution. The thing is I have never used them inmy life before so was a bit scared of using them. Has anyone else had to use them and if so are they effective and safe:sigh: